Copper-catalyzed domino cyclization of anilines and cyclobutanone oxime: a scalable and versatile route to spirotetrahydroquinoline derivatives

Copper-catalyzed domino cyclization of anilines and cyclobutanone oxime: a scalable and versatile route to spirotetrahydroquinoline derivatives

Blog Article

In this study, we report the copper-catalyzed synthesis of tetrahydroquinoline derivatives via a domino reaction of aniline with cyclobutanone oxime.This method demonstrates a selective approach for generating bioactive tetrahydroquinoline i want choo 60ml scaffolds, which have broad applications in pharmaceutical chemistry.The reaction conditions were optimized for the effective formation of tetrahydroquinoline derivatives with varying substituents, showing high yields k24a4 block under mild conditions.

Mechanistic studies suggest a catalytic cycle involving nucleophilic attack by the aniline on the cyclobutanone oxime, followed by cyclization to form the desired product.